Effectiveness of H5/H7 Vaccine in Preventing Avian Influenza in Turkeys
Author Information
Author(s): Toffan Anna, Beato Maria Serena, De Nardi Roberta, Bertoli Elena, Salviato Annalisa, Cattoli Giovanni, Terregino Calogero, Capua Ilaria
Primary Institution: Istituto Zooprofilattico Sperimentale delle Venezie
Hypothesis
Can the conventional inactivated bivalent H5/H7 vaccine prevent viral localization in the muscles of turkeys infected with avian influenza?
Conclusion
The study found that the vaccine effectively prevents viral localization in muscle tissue of vaccinated turkeys infected with both low and highly pathogenic avian influenza viruses.
Supporting Evidence
- Unvaccinated turkeys showed severe clinical signs and 100% mortality when infected with HPAI.
- Vaccinated turkeys did not show any clinical signs or detectable virus in blood and muscle samples.
- Viral RNA was detected in muscles of unvaccinated turkeys infected with LPAI, but no viable virus was isolated.
Takeaway
Vaccinating turkeys helps keep them healthy and stops the flu virus from hiding in their meat.
Methodology
Turkeys were vaccinated and then infected with HPAI and LPAI viruses to assess the presence of the virus in their muscles and blood.
Potential Biases
Potential bias in the selection of experimental birds and the controlled environment may affect the generalizability of the results.
Limitations
The study was conducted under controlled experimental conditions, which may not fully represent field conditions.
Participant Demographics
Commercially available 1-day-old poults were used in the study.
Digital Object Identifier (DOI)
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