Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination - United States, 2001-2010
2011

Rubella Vaccination Prevents Autism and Congenital Rubella Syndrome

publication Evidence: moderate

Author Information

Author(s): Brynn E. Berger, Ann Marie Navar-Boggan, Saad B. Omer

Primary Institution: Emory University

Hypothesis

How many cases of congenital rubella syndrome (CRS) and autism spectrum disorder (ASD) were prevented by rubella vaccination in the United States from 2001 to 2010?

Conclusion

Rubella vaccination prevented a significant number of cases of congenital rubella syndrome and autism spectrum disorder in the United States from 2001 to 2010.

Supporting Evidence

  • An estimated 16,600 cases of congenital rubella syndrome were prevented by rubella vaccination from 2001 to 2010.
  • Approximately 1,228 cases of autism spectrum disorder were prevented during the same period.
  • The estimates suggest that rubella vaccination has significant public health benefits.

Takeaway

Getting vaccinated against rubella helps stop babies from being born with serious problems and can also prevent some kids from developing autism.

Methodology

Estimates were calculated using simple mathematical modeling based on published literature.

Potential Biases

The reliance on historical data for model parameters may introduce bias in the estimates.

Limitations

The study relies on estimates from older studies and may not account for all variables affecting CRS and ASD incidence.

Digital Object Identifier (DOI)

10.1186/1471-2458-11-340

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