Serum Biomarkers and Dual Decline in Cognitive and Motor Functions
Author Information
Author(s): Pinardi Elena, Ornago Alice, Grande Giulia, Valletta Martina, Rizzuto Debora, Laukka Erika Jonsson, Bellelli Giuseppe, Vetrano Davide Liborio
Primary Institution: Karolinska Institutet
Hypothesis
This study aims to explore the association between serum biomarkers of Alzheimer’s disease and various patterns of cognitive/motor decline.
Conclusion
The study found that certain serum biomarkers are associated with a higher risk of dual decline in cognitive and motor functions.
Supporting Evidence
- Individuals with dual decline face an increased risk of dementia and other adverse health outcomes.
- Phosphorylated tau181, neurofilament light chain, and phosphorylated tau181/amyloid-β42 ratio were associated with the highest risk of dual decline.
- Distinct profiles of serum AD biomarkers were observed in dual decliners.
Takeaway
Some people get worse at thinking and moving at the same time, and this study looks at blood markers that might help explain why.
Methodology
Data were drawn from the Swedish National Study on Aging and Care in Kungsholmen, assessing cognitive and motor decline over 15 years using linear mixed models.
Limitations
The underlying pathophysiology remains largely unknown and requires further research.
Participant Demographics
Participants included individuals categorized into slow/non-decliners, fast motor decliners, fast cognitive decliners, and dual decliners.
Statistical Information
Confidence Interval
95% CI: 1.60;1.97
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website