Genomes of Helicobacter pylori from Native Peruvians
Author Information
Author(s): Devi S Manjulata, Ahmed Irshad, Khan Aleem A, Rahman Syed Asad, Alvi Ayesha, Sechi Leonardo A, Ahmed Niyaz
Primary Institution: Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Hypothesis
How different waves of human migrations in South America contributed to the evolution of strain diversity of H. pylori.
Conclusion
The study suggests that ancestral H. pylori strains in Peru survived and competed against Spanish strains after acquiring pathogenicity sequences.
Supporting Evidence
- Approximately 20% of native Peruvian strains represent a sub-population with Amerindian ancestry.
- All strains harbored a complete, 'western' type cagPAI.
- Phylogenetic analyses linked about 20% of the Peruvian isolates to Amerindian genotype.
Takeaway
Scientists studied bacteria from Peru to see how they changed over time, finding that some old bacteria mixed with newer ones from Europe.
Methodology
The study used fluorescent amplified fragment length polymorphism (FAFLP) analysis and multilocus sequence typing (MLST) of 7 housekeeping genes.
Limitations
The clinical background of individual isolates was not taken into account.
Participant Demographics
Native Peruvians mainly of Amerindian ancestry from Lima.
Digital Object Identifier (DOI)
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