Effects of Esculentoside A on TNF Production
Author Information
Author(s): Fang Jun, Zheng Qin Yue, Wang Hong Bin, Ju Dian Wen, Yi Yang Hua
Primary Institution: Second Military Medical University
Hypothesis
Does Esculentoside A (EsA) alter TNF production from macrophages under LPS stimulated conditions?
Conclusion
Esculentoside A significantly decreases TNF production from macrophages in a dose-dependent manner.
Supporting Evidence
- EsA decreased both extracellular and cell associated TNF production in a dose dependent manner.
- Significant reductions in TNF production were observed at concentrations of 1 and 10 μmol/L EsA.
- EsA also reduced the release of platelet activating factor from macrophages.
Takeaway
Esculentoside A helps reduce a substance in the body that causes inflammation, making it potentially useful for treating inflammatory conditions.
Methodology
Mice were treated with thioglycolate to harvest peritoneal macrophages, which were then stimulated with LPS and treated with varying concentrations of EsA to measure TNF production.
Participant Demographics
Inbred C57BL/6 mice, aged 8-10 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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