Identifying Genes in Ewing Sarcoma
Author Information
Author(s): Suvi Savola, Arto Klami, Abhishek Tripathi, Tarja Niini, Massimo Serra, Piero Picci, Samuel Kaski, Diana Zambelli, Katia Scotlandi, Sakari Knuutila
Primary Institution: University of Helsinki
Hypothesis
The study aims to pinpoint genomic regions and potential target genes involved in the tumorigenesis of Ewing sarcoma family of tumors (ESFT).
Conclusion
Array CGH and integration analysis proved effective in identifying chromosome regions and novel target genes involved in the tumorigenesis of ESFT.
Supporting Evidence
- 87% of the cases showed copy number changes.
- Patients with three or fewer copy number changes had significantly better survival rates.
- 20 novel ESFT associated putative oncogenes and tumor suppressor genes were identified.
Takeaway
Researchers looked at tumor samples from kids with a type of bone cancer to find important genes that might help us understand how the cancer grows.
Methodology
The study used array comparative genomic hybridization (CGH) and expression arrays to analyze copy number alterations and gene expression in ESFT patient samples.
Limitations
The sample size was not large enough to draw definitive conclusions about the prognostic value of HDGF expression.
Participant Demographics
The mean age of patients was 20.7 years, with a male-to-female ratio of 22:9.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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