Growth Factors and Angiogenesis in Lung Cancer
Author Information
Author(s): O'Byrne K J, Koukourakis M I, Giatromanolaki A, Cox G, Turley H, Steward W P, Gatter K, Harris A L
Primary Institution: University Department of Oncology, Leicester Royal Infirmary
Hypothesis
The expression of VEGF and PD-ECGF correlates with angiogenesis and poor outcomes in non-small-cell lung cancer.
Conclusion
VEGF and PD-ECGF are important angiogenic growth factors with prognostic significance in non-small-cell lung cancer.
Supporting Evidence
- High microvessel density correlates with increased tumor size and poor prognosis in NSCLC.
- VEGF and PD-ECGF expression are associated with high vascular grade tumors.
- Tumor size and microvessel density are significant prognostic factors.
Takeaway
This study found that certain growth factors in lung cancer can help predict how serious the disease is.
Methodology
A retrospective study evaluated VEGF and PD-ECGF expression and microvessel density in surgically resected specimens from patients with operable NSCLC.
Participant Demographics
Patients with operable non-small-cell lung cancer (T1–3, N0–2).
Statistical Information
P-Value
P = 0.009 and P = 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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