Acceptability of Genetic Testing for Paget's Disease
Author Information
Author(s): Anne L Langston, Marie Johnston, Jill Francis, Clare Robertson, Marion K Campbell, Vikki A Entwistle, Theresa Marteau, Graeme MacLennan, John Weinman, Marilyn McCallum, Zosia Miedzybrodska, Keith Charnock, Stuart H Ralston
Primary Institution: University of Edinburgh
Hypothesis
Would relatives of people with Paget's disease accept genetic testing and preventive treatment if available?
Conclusion
The study aims to assess the acceptability of genetic testing and preventive treatment among relatives of individuals with Paget's disease.
Supporting Evidence
- Paget's disease affects about 2% of individuals over the age of 55 in the UK.
- Genetic factors play a significant role in Paget's disease, with mutations identified in several genes.
- The study will use established models of social cognition to explore acceptability.
Takeaway
This study is trying to find out if family members of people with Paget's disease would be okay with getting tested for it and possibly taking medicine to prevent it.
Methodology
A postal questionnaire study targeting non-affected relatives of Paget's disease patients to assess factors influencing the acceptability of genetic testing and preventive treatment.
Potential Biases
Potential biases may arise from self-selection of participants and the subjective nature of self-reported measures.
Limitations
The study may not account for all demographic variations and relies on self-reported data.
Participant Demographics
Relatives of Paget's disease patients, including those with and without a family history of the disease.
Digital Object Identifier (DOI)
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