Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart
2008
p57Kip2 Protects Heart Cells from Injury
Sample size: 53
publication
Evidence: moderate
Author Information
Author(s): Haley Sheila A, Zhao Ting, Zou Lijun, Klysik Jan E, Padbury James F, Kochilas Lazaros K
Primary Institution: Brown University
Hypothesis
p57Kip2 has a protective role in cardiomyocytes under hypoxic conditions.
Conclusion
Forced cardiac expression of p57Kip2 does not affect heart development but protects against ischemia-reperfusion injury.
Supporting Evidence
- Transgenic mice with cardiac specific overexpression of p57Kip2 are viable and fertile.
- After ischemia-reperfusion injury, p57Kip2 overexpressing hearts showed preserved cardiac function.
- Higher left ventricular developed pressure was observed in p57Kip2 overexpressing hearts compared to controls.
Takeaway
Scientists made a special mouse that has more of a protein called p57Kip2 in its heart cells, and they found that this helps the heart recover better after being hurt by a lack of oxygen.
Methodology
Transgenic mice were created to express p57Kip2 specifically in cardiac tissue, and their hearts were subjected to ischemia-reperfusion injury to assess function.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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