Study of Genes Related to Lung Function
Author Information
Author(s): Obeidat Ma'en, Wain Louise V., Shrine Nick, Kalsheker Noor, Artigas Maria Soler, Repapi Emmanouela, Burton Paul R., Johnson Toby, Ramasamy Adaikalavan, Zhao Jing Hua, Zhai Guangju, Huffman Jennifer E., Vitart Veronique, Albrecht Eva, Igl Wilmar, Hartikainen Anna-Liisa, Pouta Anneli, Cadby Gemma, Hui Jennie, Palmer Lyle J., Hadley David, McArdle Wendy L., Rudnicka Alicja R., Barroso Inês, Loos Ruth J. F., Wareham Nicholas J., Mangino Massimo, Soranzo Nicole, Spector Tim D., Gläser Sven, Homuth Georg, Völzke Henry, Deloukas Panos, Granell Raquel, Henderson John, Grkovic Ivica, Jankovic Stipan, Zgaga Lina, Polašek Ozren, Rudan Igor, Wright Alan F., Campbell Harry, Wild Sarah H., Wilson James F., Heinrich Joachim, Imboden Medea, Probst-Hensch Nicole M., Gyllensten Ulf, Johansson Åsa, Zaboli Ghazal, Mustelin Linda, Rantanen Taina, Surakka Ida, Kaprio Jaakko, Jarvelin Marjo-Riitta, Hayward Caroline, Evans David M., Koch Beate, Musk Arthur William, Elliott Paul, Strachan David P., Tobin Martin D., Sayers Ian, Hall Ian P., Consortium SpiroMeta
Primary Institution: University Hospital of Nottingham, Nottingham, United Kingdom
Hypothesis
Are single nucleotide polymorphisms (SNPs) in previously reported genetic regions associated with lung function in a large population sample?
Conclusion
The study found no strong evidence for association between previously reported lung function genes and lung function measures in the general population.
Supporting Evidence
- The study included a large sample size of 20,288 individuals.
- No SNPs showed significant association with lung function measures after correction for multiple testing.
- The strongest association with FEV1 was found with SNPs in the MACROD2 gene.
Takeaway
The researchers looked at genes that might affect how well people can breathe, but they didn't find strong links between these genes and lung function in most people.
Methodology
The study analyzed SNPs tagging 130 genes and 48 intergenic regions after a systematic literature review.
Limitations
The study may not detect modest effects of genetic variants on lung function due to conservative testing and the focus on a general population.
Participant Demographics
Participants were from the general population, primarily of European descent.
Statistical Information
P-Value
6.81×10−5
Statistical Significance
p<1.3×10−5
Digital Object Identifier (DOI)
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