Decellularization of fish tissues for tissue engineering and regenerative medicine applications
2025

Decellularization of Fish Tissues for Tissue Engineering

publication Evidence: moderate

Author Information

Author(s): Wenhui Chen, Mengshi Chen, Siyi Chen, Siran Wang, Zijin Huang, Lining Zhang, Jiaming Wu, Weijie Peng, Huaqiong Li, Feng Wen

Primary Institution: Wenzhou Institute, University of Chinese Academy of Sciences

Hypothesis

Decellularization of fish tissues can provide acellular scaffolds with low immunogenicity and high biocompatibility for tissue engineering applications.

Conclusion

Decellularized fish tissues exhibit good mechanical properties and biocompatibility, making them promising materials for various tissue engineering applications.

Supporting Evidence

  • Decellularized fish tissues retain the structure and bioactive components of their native tissues.
  • Fish tissues are less likely to transmit zoonotic diseases compared to mammalian tissues.
  • Decellularization methods can be tailored to preserve the mechanical properties of the extracellular matrix.

Takeaway

Scientists are using fish parts to make materials that can help heal injuries because these materials are safe and work well with our bodies.

Methodology

The review discusses various physical, chemical, and enzymatic methods for decellularizing fish tissues to create acellular scaffolds.

Limitations

The review does not provide specific quantitative data on the effectiveness of each decellularization method.

Digital Object Identifier (DOI)

10.1093/rb/rbae138

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