Hearing Loss in Nasopharyngeal Cancer Patients After Chemoradiotherapy
Author Information
Author(s): Petsuksiri Janjira, Sermsree Achariyaporn, Thephamongkhol Kullathorn, Keskool Phawin, Thongyai Kanthong, Chansilpa Yaowalak, Pattaranutaporn Pittayapoom
Primary Institution: Division of Radiation Oncology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
Hypothesis
This study aims to review the incidences of sensorineural hearing loss (SNHL) when treating nasopharyngeal cancer patients with different radiation techniques.
Conclusion
IMRT and limiting radiation doses to the inner ear appear to decrease the incidence of sensorineural hearing loss.
Supporting Evidence
- The incidence of high frequency SNHL was 44% for the whole group.
- The incidence of SNHL was lower in patients treated with IMRT compared to conventional RT.
- Mean radiation doses to the cochlea were about 50 Gy.
Takeaway
This study found that patients with nasopharyngeal cancer can lose their hearing after treatment, but using a specific type of radiation therapy can help protect their hearing.
Methodology
A retrospective cohort study of 134 individual ears from 68 NPC patients treated with conventional RT and IMRT in combination with chemotherapy was performed.
Potential Biases
Potential bias from incomplete audiometric evaluations and reliance on pre and post RT audiograms.
Limitations
The study's retrospective design and shorter follow-up time may limit the evaluation of transient hearing loss.
Participant Demographics
Patients aged 18-70 years, with a median age of 47.5 years; 65% were ≤ 50 years old.
Statistical Information
P-Value
0.047
Confidence Interval
95% CI 1.01-4.03
Statistical Significance
p = 0.047
Digital Object Identifier (DOI)
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