C-reactive protein and survival in colorectal cancer patients
Author Information
Author(s): Crozier J E M, McKee R F, McArdle C S, Angerson W J, Anderson J H, Horgan P G, McMillan D C
Primary Institution: University Department of Surgery, Royal Infirmary, Glasgow
Hypothesis
Does the presence of a systemic inflammatory response, indicated by C-reactive protein levels, predict survival in patients receiving adjuvant chemotherapy for colorectal cancer?
Conclusion
An elevated C-reactive protein concentration is associated with poorer survival in patients receiving adjuvant 5-FU chemotherapy after colorectal cancer surgery.
Supporting Evidence
- An elevated C-reactive protein concentration was significantly associated with survival in patients receiving adjuvant chemotherapy.
- The study included 222 patients undergoing potentially curative resection for colorectal cancer.
Takeaway
If a patient has high levels of a protein called C-reactive protein, it might mean they won't do as well after surgery and chemotherapy for colon cancer.
Methodology
The study evaluated C-reactive protein levels and survival in 222 patients who underwent surgery for colorectal cancer, with some receiving adjuvant chemotherapy.
Limitations
The study is small and further larger studies are required to confirm these results.
Participant Demographics
The majority of patients were aged 65 years or more, with a mix of male and female participants.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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