4-{4-Methyl-2-[(methyl)(2-methylphenyl)amino]-1,3-thiazol-5-yl}-N-(3-methylphenyl)pyrimidin-2-amine
2011
Study of a New Thiazole-Pyrimidine Compound
publication
Evidence: moderate
Author Information
Author(s): Shi Hai-Bo, Xu Feng, Li Hai-Bo, Hu Wei-Xiao
Primary Institution: Zhejiang Pharmaceutical College
Hypothesis
The introduction of an arylamino group into the thiazole ring of thiazolyl-pyrimidine derivatives will affect their biological activity.
Conclusion
The crystal structure of the compound was successfully determined using single-crystal X-ray diffraction.
Supporting Evidence
- The thiazole and pyrimidine rings in the compound are almost coplanar.
- Weak intermolecular N—H⋯N interactions link pairs of molecules into centrosymmetric dimers.
- The compound was synthesized using a mixture of specific chemicals and heated under controlled conditions.
Takeaway
Scientists made a new chemical compound and looked at its structure using special X-ray techniques to see how it might work in the body.
Methodology
The compound was synthesized and its structure was analyzed using single-crystal X-ray diffraction.
Limitations
The initial compound obtained was not suitable for X-ray diffraction studies.
Digital Object Identifier (DOI)
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