Thyroid Hormones and Interleukins in Non-Thyroidal Illnesses
Author Information
Author(s): Abo-Zenah Hamdy, Shoeb Sabry, Sabry Alaa, Ismail Hesham
Primary Institution: Menufiya University, Egypt
Hypothesis
The study aims to elucidate the relationship between interleukins IL-6 and IL-10 and thyroid hormone concentrations in patients with non-thyroidal illnesses.
Conclusion
The high prevalence of euthyroid sick syndrome in non-thyroidal illnesses may be linked to alterations in IL-6 and IL-10 levels.
Supporting Evidence
- Patients with non-thyroidal illnesses showed significantly lower T3 and T4 levels compared to healthy controls.
- IL-6 levels were significantly higher in patients with non-thyroidal illnesses compared to controls.
- IL-6 correlated negatively with T3 and T4 levels in patients.
Takeaway
When people are sick but don't have thyroid problems, their thyroid hormone levels can drop, and this might be connected to certain chemicals in the body called interleukins.
Methodology
The study involved 60 patients with non-thyroidal illnesses and 20 healthy volunteers, measuring serum levels of IL-6, IL-10, TSH, T3, and T4.
Limitations
The study is observational and may not establish causation.
Participant Demographics
60 patients (46 men, 14 women; aged 45 ± 19 years) and 20 healthy volunteers (15 men, 5 women; aged 39 ± 5 years).
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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