FBP Proteins as Regulators of c-myc in Kidney Cancer
Author Information
Author(s): Weber Achim, Kristiansen Ilka, Johannsen Manfred, Oelrich Beibei, Scholmann Katharina, Gunia Sven, May Matthias, Meyer Hellmuth-Alexander, Behnke Silvia, Moch Holger, Kristiansen Glen
Primary Institution: University Hospital Zurich, Zurich, Switzerland
Hypothesis
The study investigates the role of FUSE binding proteins FBP1 and FBP3 as regulators of the c-myc proto-oncogene in different types of urogenital cancers.
Conclusion
FBP1 and FBP3 are associated with c-myc up-regulation in renal cell carcinoma, suggesting they act as activators of c-myc in this cancer type.
Supporting Evidence
- FBP1 and FBP3 were frequently expressed in renal cell carcinoma.
- High FBP1 expression was associated with c-myc up-regulation in clear cell renal cell carcinoma.
- FBP1 and FBP3 expression levels were not significantly correlated with prostate and bladder cancers.
Takeaway
FBP1 and FBP3 are proteins that help control a gene called c-myc, which is important for cancer growth, especially in kidney cancer.
Methodology
The expression of FBP1, FBP3, and c-myc was studied in 105 renal cell, 95 prostate, and 112 urinary bladder carcinomas using immunohistochemistry on tissue microarrays.
Limitations
The study primarily focuses on specific cancer types and may not generalize to all cancers.
Participant Demographics
The study included adult patients with renal cell carcinoma, prostate cancer, and bladder cancer.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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