Melanin-concentrating hormone reduces pleasure-driven eating in mice
Author Information
Author(s): Liu Xiaoning, Yang Helin, Xu Wenguang, Wang Xuezhe, Tang Wenhui, Wang Xiaoxuan, Jiao Yang, Luan Xinchi, Li Pengmeng, Guo Feifei
Primary Institution: Qingdao University, Qingdao, Shandong, China
Hypothesis
The motivation for food seeking driven by OX-A is modified by HFD, while MCH regulates the excitatory effect of OX-A on the VTADA neurons.
Conclusion
Melanin-concentrating hormone could attenuate the hedonic feeding behavior induced by orexin-A in the VTA of HFD mice.
Supporting Evidence
- Sucrose intake resulted in lower activation of VTA neurons in the HFD mice compared to CON mice.
- Chemogenetic inhibition of MCH neurons improved the activity of OXR1-expressing neurons.
- Administration of MCHR1 antagonist significantly potentiated the effect of OX-A.
Takeaway
This study found that a hormone called melanin-concentrating hormone helps control how much pleasure mice get from eating tasty food, especially when they eat a lot of fat.
Methodology
Male mice were fed a high-fat diet for 8 weeks, and various tests were conducted to assess the effects of MCH and OX-A on feeding behavior and neuronal activity.
Limitations
The study primarily focused on male mice, which may limit the generalizability of the findings to females.
Participant Demographics
Healthy male KunMing mice, 3-week-old at the start of the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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