Genetic Factors and Pancreatic Cancer Risk
Author Information
Author(s): G Liu, P Ghadirian, D Vesprini, N Hamel, A-J Paradis, G Lal, S Gallinger, S A Narod, W D Foulkes
Primary Institution: Centre for Research in Women's Health, Women's College Hospital, University of Toronto
Hypothesis
Do polymorphisms in GSTM1, GSTT1, and CYP1A1 increase the risk of pancreatic adenocarcinoma?
Conclusion
The study found no significant associations between the tested genetic polymorphisms and the risk of pancreatic cancer.
Supporting Evidence
- The study included 149 cases of pancreatic adenocarcinoma and 146 controls.
- No associations were found between GSTM1, GSTT1, and CYP1A1 polymorphisms and pancreatic cancer susceptibility.
- Smoking and drinking status did not affect the results.
Takeaway
The study looked at whether certain genes could make people more likely to get pancreatic cancer, but it found that they don't.
Methodology
A prospective study comparing 149 pancreatic cancer cases with 146 matched controls.
Participant Demographics
Unselected incident cases of pancreatic adenocarcinoma and ethnically-matched controls.
Digital Object Identifier (DOI)
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