The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research
Author Information
Author(s): Sanfelice Domenico, Antolin Albert, Crisp Alisa, Chen Yi, Bellenie Benjamin, Brennan Paul E, Edwards Aled, Müller Susanne, Al-Lazikani Bissan, Workman Paul
Primary Institution: The Institute of Cancer Research, London
Conclusion
The Chemical Probes Portal has significantly expanded its database of chemical probes and improved its functionalities to better support researchers in selecting and using high-quality chemical probes.
Supporting Evidence
- The number of chemical probes has increased from 547 to 803, a 47% growth.
- About 82% of the compounds have been peer reviewed.
- 85% of the reviewed probes received a rating of 3 or 4 stars for use in cells.
Takeaway
The Chemical Probes Portal helps scientists find and use the best small molecules for their research, making sure they get accurate results.
Methodology
The Portal provides expert reviews and guidance on small-molecule probes, with a focus on user engagement and community contributions.
Limitations
Despite improvements, low-quality compounds are still commonly used, leading to incorrect conclusions in research.
Digital Object Identifier (DOI)
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