Homocysteine as a Risk Factor for Atherosclerosis: Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?
2011
Homocysteine and Its Role in Atherosclerosis and Lipid Metabolism
publication
Evidence: moderate
Author Information
Author(s): Oksana Tehlivets
Primary Institution: Institute of Molecular Biosciences, University of Graz
Hypothesis
Is the conversion of homocysteine to S-adenosyl-L-homocysteine the key to deregulated lipid metabolism?
Conclusion
The study proposes that elevated homocysteine levels lead to lipid metabolism deregulation through the accumulation of S-adenosyl-L-homocysteine.
Supporting Evidence
- Homocysteine is recognized as a risk factor for atherosclerosis.
- Accumulation of S-adenosyl-L-homocysteine inhibits phospholipid methylation.
- Elevated homocysteine levels are linked to increased triacylglycerol synthesis.
Takeaway
Homocysteine can cause problems in the body by messing up how fats are processed, which might lead to heart disease.
Digital Object Identifier (DOI)
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