Fatality from Ibuprofen Overdose
Author Information
Author(s): Wood David Michael, Monaghan Jane, Streete Peter, Jones Alison Linda, Dargan Paul Ivor
Primary Institution: Guy's and St Thomas' Poisons Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK
Hypothesis
Isolated toxicity from sustained-release ibuprofen can lead to fatal outcomes.
Conclusion
The case highlights that severe poisoning from sustained-release ibuprofen can be fatal despite intensive medical intervention.
Supporting Evidence
- Severe toxicity from ibuprofen is rare, with most patients being asymptomatic or having mild symptoms.
- This case is the first reported death from isolated sustained-release ibuprofen poisoning.
- The patient ingested a lethal dose of up to 105 g of ibuprofen.
- Despite intensive care, the patient did not survive due to severe metabolic acidosis and hemodynamic compromise.
Takeaway
A woman took too much ibuprofen and got very sick, and even with help from doctors, she didn't survive.
Methodology
The case involved a detailed clinical assessment and toxicology screening of the patient before and after death.
Limitations
The case report is based on a single patient, limiting generalizability.
Participant Demographics
A 26-year-old female with no significant past medical history.
Digital Object Identifier (DOI)
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