How SXR Activation Kills Breast Cancer Cells
Author Information
Author(s): Verma Suman, Tabb Michelle M, Blumberg Bruce
Primary Institution: University of California, Irvine
Hypothesis
SXR activation mediates the anti-proliferative effects of certain compounds in breast cancer cells.
Conclusion
Activation of SXR inhibits breast cancer cell growth by inducing apoptosis through a nitric oxide and p53-dependent mechanism.
Supporting Evidence
- SXR activation leads to increased expression of p53 and pro-apoptotic genes.
- SXR activators induce cell cycle arrest at the G1/S phase.
- Inhibition of iNOS blocks the induction of p53.
- p53 knockdown inhibits up-regulation of cell cycle regulatory genes.
Takeaway
When certain compounds activate a receptor called SXR in breast cancer cells, it helps to stop the cells from growing and can even make them die.
Methodology
The study measured breast cancer cell proliferation in response to SXR activators and analyzed gene expression changes using quantitative RT-PCR and western blotting.
Participant Demographics
The study focused on breast cancer cell lines MCF-7 and ZR-75-1.
Statistical Information
P-Value
≤ 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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