How Scc4 Helps Cells Stick Together and Move
Author Information
Author(s): Seitan Vlad C, Banks Peter, Laval Steve, Majid Nazia A, Dorsett Dale, Rana Amer, Smith Jim, Bateman Alex, Krpic Sanja, Hostert Arnd, Rollins Robert A, Erdjument-Bromage Hediye, Tempst Paul, Benard Claire Y, Hekimi Siegfried, Newbury Sarah F, Strachan Tom
Primary Institution: Institute of Human Genetics, University of Newcastle
Hypothesis
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
Conclusion
The study shows that Scc4 homologs in metazoans are involved in both sister chromatid cohesion and the guidance of cell and axon migration during development.
Supporting Evidence
- Scc4 homologs are evolutionarily conserved across metazoans.
- Knockdown of human MAU-2 resulted in precocious sister chromatid separation.
- MAU-2 regulates chromosome segregation in C. elegans embryos.
- Delangin and MAU-2 are involved in similar developmental pathways in Xenopus tropicalis.
Takeaway
This research found that a protein called Scc4 helps cells stick together when they divide and also helps them move to the right places in the body.
Methodology
The study used RNA interference and protein interaction assays to investigate the roles of Scc4 and its homologs in cell division and migration.
Statistical Information
P-Value
p<10−6
Statistical Significance
p<10−6
Digital Object Identifier (DOI)
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