Micronutrient Supplementation Improves Vitamin B12 and Folate in HIV-Infected Children
Author Information
Author(s): Ndeezi Grace, Tumwine James K, Ndugwa Christopher M, Bolann Bjørn J, Tylleskär Thorkild
Primary Institution: Makerere University, Kampala, Uganda
Hypothesis
Supplementation with two recommended dietary allowances (RDA) of 14 multiple micronutrients (MMS) would increase serum vitamin B12 and folate concentrations compared to a 1 RDA of 6 multivitamin (MV) 'standard of care' supplement.
Conclusion
Multiple micronutrient supplementation improved the vitamin B12 and folate status of HIV infected children in Uganda.
Supporting Evidence
- 60 out of 214 children had low vitamin B12 concentrations.
- 62 out of 214 children had low folate concentrations.
- The median vitamin B12 concentration increased significantly in the MMS group after 6 months.
- The median folate concentration also increased significantly in the MMS group after 6 months.
- No significant difference was observed in the MV group.
Takeaway
Giving extra vitamins to sick kids helps them get better levels of important nutrients like vitamin B12 and folate.
Methodology
A randomized controlled trial with 847 children, where 214 were assessed for vitamin B12 and folate concentrations pre and post supplementation.
Limitations
The study did not include a control group of HIV uninfected children and had limited blood samples for biochemical tests.
Participant Demographics
HIV infected children aged 1-5 years, with equal representation of males and females.
Statistical Information
P-Value
<0.001
Confidence Interval
IQR not specified
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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