Effectiveness of Bisoprolol in Patients with Non-obstructive Coronary Artery Disease
Author Information
Author(s): Muacevic Alexander, Adler John R, Pinto Brian, Kulkarni Girish R, Kumar Soumitra, Deb Arup, Fischer Louie, Khandelwal Amit, Korukonda Krishnaprasad R, Nair Rathish
Primary Institution: Torrent Pharmaceuticals Ltd.
Hypothesis
Does bisoprolol improve clinical outcomes in patients with non-obstructive coronary artery disease who underwent percutaneous coronary intervention?
Conclusion
Bisoprolol is effective in reducing resting heart rate and improving left ventricular ejection fraction in Indian patients with non-obstructive coronary artery disease after percutaneous coronary intervention.
Supporting Evidence
- Bisoprolol significantly reduced resting heart rate by 12.14 bpm in non-obstructive coronary artery disease patients.
- Left ventricular ejection fraction improved by 4.68% after 24 weeks of bisoprolol treatment.
- Adverse events were mild and did not require treatment withdrawal.
Takeaway
This study shows that a medicine called bisoprolol can help people with heart problems feel better and have healthier hearts.
Methodology
Post-hoc analyses of patients with non-obstructive coronary artery disease from cross-sectional studies across 80 centers in India.
Potential Biases
Potential bias due to the observational nature of the study.
Limitations
The study has a smaller sample size and a relatively short follow-up duration.
Participant Demographics
Mean age of participants was 58.63 years, with 76.37% males and 23.63% females.
Statistical Information
P-Value
<0.01
Confidence Interval
(-14.90, -13.10)
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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