Different Types of Liver Cells Store Retinoids and Lipids Differently
Author Information
Author(s): D'Ambrosio Diana N., Walewski José L., Clugston Robin D., Berk Paul D., Rippe Richard A., Blaner William S.
Primary Institution: Columbia University
Hypothesis
Does the hepatic stellate cell population in a healthy liver show differences in their ability to store retinoids and lipids?
Conclusion
The study found that there are distinct populations of hepatic stellate cells in the liver, with some being 'primed' for rapid response to liver injury.
Supporting Evidence
- GFP-HSCs have increased expression of markers of HSC activation.
- GFP-HSCs show decreased levels of retinyl esters and triglycerides.
- GFP-HSCs express higher levels of genes associated with lipid catabolism.
- CYP2S1 is expressed at higher levels in GFP-HSCs.
Takeaway
Some liver cells are better at storing vitamins and fats than others, and this helps them respond quickly when the liver gets hurt.
Methodology
The study used two methods to isolate hepatic stellate cells based on their vitamin A content and collagen expression.
Participant Demographics
Male mice aged 90 to 120 days
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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