Evolutionary Rates in Alternative Exons and Splicing Regulation
Author Information
Author(s): Mireya Plass, Eduardo Eyras
Primary Institution: IMIM – Pompeu Fabra University
Hypothesis
The study investigates the relationship between the conservation of exonic structures and the evolutionary rates of alternative and constitutive exons.
Conclusion
The differences in evolutionary rates between alternative and constitutive exons can largely be explained by the conservation of the transcript exonic structure.
Supporting Evidence
- Alternative exons in transcripts with non-conserved structures have higher substitution rates.
- Constitutive exons show higher conservation in the arrangement of splicing enhancers.
- The study found significant differences in evolutionary rates between alternative and constitutive exons.
Takeaway
This study looks at how different parts of genes change over time and how that affects how genes work, especially when they can be switched on or off.
Methodology
The study analyzed a large set of protein coding exons conserved between human and mouse, focusing on the evolutionary rates of alternative and constitutive exons.
Statistical Information
P-Value
< 2.2e-16
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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