Effective prevention of the nephrotoxicity of cis-platin (CDDP) by administration of sodium 2-mercaptoethane-sulfonate (MESNA) in rats
1985
Preventing Kidney Damage from Cisplatin in Rats
Sample size: 45
publication
Evidence: high
Author Information
Author(s): S.R. Kempf, S. Ivankovic, M. Wiessler, D. Schmahl
Primary Institution: Institute for Toxicology and Chemotherapy, German Cancer Research Centre
Hypothesis
Can sodium 2-mercaptoethane-sulfonate (MESNA) prevent the nephrotoxicity of cisplatin in rats?
Conclusion
The study found that MESNA can completely protect the kidneys of rats from damage caused by cisplatin.
Supporting Evidence
- After treatment with MESNA, only 11% of rats showed severe kidney damage compared to 87% in the control group.
- The study established a clear dose/effect relationship for MESNA's protective effects.
- Histological examination revealed that 70% of the rats treated with MESNA had no renal lesions.
Takeaway
Researchers gave rats a medicine called MESNA before a cancer drug, and it helped keep their kidneys safe from harm.
Methodology
The study involved administering cisplatin to rats and then giving them MESNA to observe its protective effects on the kidneys.
Participant Demographics
BD IX rats
Want to read the original?
Access the complete publication on the publisher's website