Effects of Metal Ions on Anti-Candida Metabolite Production by Aspergillus sp.
Author Information
Author(s): Santos Anne Karoline Maiorana, dos Santos Bianca Araújo, Farias Josivan Regis, de Morais Sebastião Vieira, Vasconcelos Cleydlenne Costa, Guerra Rosane Nassar Meireles, Rodrigues-Filho Edson, Lopes Alberto Jorge Oliveira, Cantanhede Filho Antônio José
Primary Institution: Federal Institute of Science Education and Technology of Maranhão
Hypothesis
The study investigates how Mn(II) and Co(II) ions affect the production of antifungal metabolites by the endophytic fungus Aspergillus sp.
Conclusion
Mn(II) and Co(II) significantly enhanced the production of antifungal metabolites in Aspergillus sp., with fonsecinone B showing the most promise for antifungal therapy.
Supporting Evidence
- Key metabolites showed antifungal activity with MIC values of 4.37–280.61 µg/mL.
- Fonsecinone B exhibited superior biofilm inhibition compared to fluconazole.
- In vivo assays showed low toxicity with survival rates above 80% at 2× MIC/kg.
Takeaway
This study found that adding certain metals to fungus can help it make better medicine to fight bad germs.
Methodology
The fungus was cultivated in Czapek agar with metal ions, and metabolite profiles were analyzed using UHPLC-DAD and LC-ESI-HRMS.
Limitations
The study primarily focuses on in vitro results, and further in vivo studies are needed to confirm findings.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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