Sex Differences in Frailty and Aging in Mice
Author Information
Author(s): Wu Judy, Samuelson Brady, Betz Elizabeth, Kane Alice
Primary Institution: Institute for Systems Biology
Hypothesis
How does frailty influence behavioral and molecular assessments of aging in male and female mice?
Conclusion
Preliminary data suggest that frailty scores decrease over time, with notable differences in behavioral and blood outcomes between sexes.
Supporting Evidence
- Frailty scores decrease over time.
- Females have higher nesting scores at all timepoints.
- Males have higher white blood cell counts than females.
- Glucose levels increase over time for both sexes.
- Males have lower glucose counts than females.
- Frailty is associated with lower glucose levels in both sexes.
- Heart rate is higher in females and increases over time for both sexes.
- Higher frailty scores are associated with lower heart rates in both sexes.
Takeaway
This study looks at how being frail affects aging in male and female mice, finding that frailty scores can actually go down over time.
Methodology
Longitudinal measurements of frailty indices, behavioral assessments, and blood outcomes in UM-HET3 mice.
Limitations
Data collection is ongoing, and more significant effects may be observed as the mice age.
Participant Demographics
UM-HET3 male and female mice.
Statistical Information
P-Value
p=9.98e-13
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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