Anti-Atherogenic Effects of Terminalia arjuna Bark in Rabbits
Author Information
Author(s): Subramaniam Saravanan, Subramaniam Ramachandran, Rajapandian Suja, Uthrapathi Subasini, Gnanamanickam Victor Rajamanickam, Dubey Govinda Prasad
Primary Institution: SASTRA University
Hypothesis
The ethanolic fraction of Terminalia arjuna bark will reduce blood lipid levels and atherosclerosis in hypercholesterolemic rabbits.
Conclusion
The study found that the ethanolic extract of Terminalia arjuna significantly lowers cholesterol and triglyceride levels while improving HDL levels in rabbits.
Supporting Evidence
- The ethanolic fraction significantly decreased total cholesterol, LDL, and triglycerides.
- HDL levels increased in the treated groups compared to the high-fat diet group.
- Atherogenic index was significantly reduced in the treatment groups.
Takeaway
This study shows that a plant called Terminalia arjuna can help lower bad fats in the blood and protect against heart problems in rabbits.
Methodology
Twenty rabbits were divided into five groups and fed different diets for 72 days, with blood lipid levels measured at multiple time points.
Limitations
The study was conducted only on rabbits, and results may not directly translate to humans.
Participant Demographics
Twenty New Zealand rabbits of either sex, weighing 1.5–2 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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