Brachytherapy for Stage II Mobile Tongue Cancer
Author Information
Author(s): Oota Sayako, Shibuya Hitoshi, Yoshimura Ryo-ichi, Watanabe Hiroshi, Miura Masahiko
Primary Institution: Tokyo Medical and Dental University
Hypothesis
This study was designed to evaluate the prognostic factors for local control based on a large population under a unified treatment policy.
Conclusion
Brachytherapy was associated with a high cure rate, and the use of spacers improved quality of life while reducing complications.
Supporting Evidence
- The primary local control rates were 85.6%.
- An invasive growth pattern was a significant factor for local recurrence.
- Old age influenced disease-related survival.
- The use of spacers lowered mandibular bone complications.
- Patients with exophytic and invasive tumors had a higher risk of local recurrence.
Takeaway
Doctors used a special type of radiation treatment called brachytherapy to help patients with tongue cancer, and it worked really well, especially when they used a spacer to protect the mouth.
Methodology
433 patients with stage II squamous cell carcinoma were treated with low-dose-rate brachytherapy over a 28-year period.
Potential Biases
Potential bias in patient selection and treatment protocols.
Limitations
The study only included patients with stage II disease and may not be generalizable to other stages.
Participant Demographics
201 males and 136 females, median age 56 years (range: 19–92 years).
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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