Muscle Mitochondrial Function and Brain Health in Older Adults
Author Information
Author(s): Rosano Caterina, Kritchevsky Stephen, Miljkovic Iva, Newman Anne, Cawthon Peggy, Cummings Stephen, Coen Paul
Primary Institution: University of Pittsburgh
Hypothesis
Higher mitochondrial energetics would be associated with higher cognitive function scores.
Conclusion
Higher mitochondrial respiration is linked to faster processing speed in older adults, regardless of other cognitive predictors.
Supporting Evidence
- Lower skeletal muscle oxidative capacity is linked with poor cognition in older adults.
- Mitochondrial respiration was measured in muscle biopsies.
- Cognitive function was assessed using the Digit Symbol Substitution Test and Montreal Cognitive Assessment.
Takeaway
If your muscles work better, your brain might work better too, especially as you get older.
Methodology
Mitochondrial respiration was measured in muscle biopsies, and cognitive function was assessed using standardized tests.
Potential Biases
Potential biases related to participant demographics and assessment methods.
Limitations
The study may not account for all factors influencing cognition.
Participant Demographics
Mean age 76.34 years, 59% female, 84% Non Hispanic White.
Statistical Information
Confidence Interval
95% CI: 0.68, 2.72
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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