Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein
2006
Olopatadine Reduces Monocyte Migration Induced by S100A12 Protein
Sample size: 9
publication
Evidence: moderate
Author Information
Author(s): Kazuya Kishimoto, Satoshi Kaneko, Kenji Ohmori, Tadafumi Tamura, Kazuhide Hasegawa
Primary Institution: Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd
Hypothesis
Does olopatadine inhibit the proinflammatory effects of S100A12?
Conclusion
Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12.
Supporting Evidence
- Olopatadine reduced the migration of THP-1 cells induced by S100A12.
- Amlexanox also inhibited THP-1 migration induced by S100A12.
- Ketotifen had little effect on the activity of S100A12.
Takeaway
Olopatadine, a medicine for allergies, can help stop certain immune cells from moving too much when a protein called S100A12 is present.
Methodology
The study involved treating THP-1 monocytes with olopatadine and measuring their migration in response to S100A12 using a cell migration assay.
Limitations
The study primarily focused on in vitro conditions, and the effects in vivo may differ.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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