Cruciform structures are a common DNA feature important for regulating biological processes
2011
The Role of Cruciform Structures in DNA Regulation
publication
Evidence: high
Author Information
Author(s): Václav Brázda, Rob C. Laister, Eva B. Jagelská, Cheryl Arrowsmith
Primary Institution: Institute of Biophysics, Academy of Sciences of the Czech Republic
Hypothesis
Cruciform structures in DNA play a significant role in regulating biological processes.
Conclusion
Cruciform structures are essential for various biological processes, including DNA replication, transcription, and gene expression regulation.
Supporting Evidence
- Cruciform structures are formed by inverted repeats in DNA.
- These structures are important for gene expression and DNA replication.
- Proteins that bind to cruciforms can influence DNA topology and gene regulation.
- Disruption of cruciform binding proteins is linked to various diseases, including cancer.
Takeaway
Cruciforms are special shapes that DNA can make, and they help control how our genes work.
Methodology
The review discusses various proteins that interact with cruciform structures and their roles in biological processes.
Digital Object Identifier (DOI)
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