Identification of the Otopetrin Domain in Vertebrates and Invertebrates
Author Information
Author(s): Inna Hughes, Jonathan Binkley, Belen Hurle, Eric D. Green, Arend Sidow, David M. Ornitz
Primary Institution: Washington University School of Medicine
Hypothesis
The study hypothesizes that the Otopetrin Domain Protein (ODP) gene family plays a conserved role in the intracellular trafficking of calcium and the formation of biominerals.
Conclusion
The study identifies a refined model for the Otopetrin Domain Protein family, suggesting a conserved role in calcium handling and biomineral formation across species.
Supporting Evidence
- Otopetrin 1 is necessary for the formation of otoconia and otoliths in the inner ear.
- The Otopetrin Domain Protein family shows high conservation across vertebrates and invertebrates.
- Mutations in Otopetrin 1 lead to loss of otoconia and balance issues in animal models.
Takeaway
This study found that a group of proteins called Otopetrins helps animals sense gravity and balance by forming tiny structures in their inner ears.
Methodology
The study involved multi-species comparison of predicted primary sequences and secondary structures of vertebrate otopetrins and related proteins from arthropods and nematodes.
Digital Object Identifier (DOI)
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