Gender Differences in Gene Expression of Human Livers
Author Information
Author(s): Delongchamp Robert R, Velasco Cruz, Dial Stacey, Harris Angela J
Primary Institution: National Center for Toxicological Research
Hypothesis
Are there gender differences in gene expression in human livers?
Conclusion
Observed gender differences in gene expression were small and difficult to identify specifically.
Supporting Evidence
- 8% of expressed genes differed by gender.
- False discovery rates exceed 80% for any set of genes selected based on p-values.
- Most observed fold changes were less than 1.55.
Takeaway
The study looked at how male and female livers express genes differently, but found that the differences are very small.
Methodology
The study used cDNA arrays to analyze gene expression in liver samples from 9 males and 9 females.
Potential Biases
Potential for excessive false positive rates due to the number of genes evaluated.
Limitations
The ability to identify specific genes with gender differences is poor due to high false discovery rates.
Participant Demographics
9 male and 9 female liver samples, age range 25-58, with some information on race and habits.
Statistical Information
P-Value
0.12
Confidence Interval
95 % CI: 7 % to 9 %
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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