Exploring Indirect Sources of Human Exposure to Perfluoroalkyl Carboxylates (PFCAs): Evaluating Uptake, Elimination, and Biotransformation of Polyfluoroalkyl Phosphate Esters (PAPs) in the Rat
2011
Study on Human Exposure to Perfluoroalkyl Carboxylates from Polyfluoroalkyl Phosphate Esters
Sample size: 8
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Jessica C. D’eon, Scott A. Mabury
Primary Institution: University of Toronto
Hypothesis
PAP biotransformation contributes to the PFCA burden observed in human sera.
Conclusion
PAP exposure should be considered a significant indirect source of human PFCA contamination.
Supporting Evidence
- DiPAPs were bioavailable, with bioavailability decreasing as the chain length increased.
- MonoPAPs were not absorbed from the gut, suggesting they may be transformed within gut contents.
- Biotransformation to PFCAs was observed for both monoPAP and diPAP congeners.
Takeaway
This study found that certain chemicals in food packaging can change in our bodies and lead to harmful substances in our blood over time.
Methodology
Rats were dosed with different chain lengths of PAPs, and their blood, urine, and feces were analyzed over time.
Limitations
The study did not observe monoPAPs in the blood, making it difficult to determine their fate in the body.
Participant Demographics
Sprague-Dawley rats were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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