No link between BAFF gene variation and primary Sjögren's syndrome
Author Information
Author(s): Gottenberg Jacques-Eric, Sellam Jérémie, Ittah Marc, Lavie Frédéric, Proust Alexis, Zouali Habib, Sordet Christelle, Sibilia Jean, Kimberly Robert P, Mariette Xavier, Miceli-Richard Corinne
Primary Institution: Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud
Hypothesis
Is BAFF over-expression in primary Sjögren's syndrome a genetically determined event?
Conclusion
The study found that BAFF gene polymorphism is not associated with genetic predisposition to primary Sjögren's syndrome or specific antibody production patterns.
Supporting Evidence
- No significant differences in allele and genotype frequencies of BAFF polymorphism were detected between patients with pSS and controls.
- T allele carriers had significantly increased BAFF protein serum levels compared to C allele carriers.
- The study included a large sample size of 252 individuals.
Takeaway
The researchers looked at a gene related to B-cell activation in people with a condition called primary Sjögren's syndrome and found no link between the gene and the disease.
Methodology
The BAFF gene was sequenced and the -871 T/C SNP was genotyped in 162 patients with primary Sjögren's syndrome and 90 healthy controls.
Limitations
The study was limited to Caucasian patients and did not assess the functional role of the BAFF polymorphism directly.
Participant Demographics
The study included 162 French patients with primary Sjögren's syndrome and 90 healthy French controls, predominantly women.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI 2.7–6.5
Statistical Significance
p=0.01
Digital Object Identifier (DOI)
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