N-(2-Chloropyrimidin-4-yl)-2-methyl-2H-indazol-6-amine methanol monosolvate
2011
Crystal Structure of a New Compound Derived from Pazopanib
publication
Evidence: high
Author Information
Author(s): Pang Xiang-Chuan, Deng Xin-Hua, Sun Yuan
Primary Institution: Tianjin Polytechnic University
Hypothesis
The study aims to determine the crystal structure of N-(2-chloropyrimidin-4-yl)-2-methyl-2H-indazol-6-amine methanol monosolvate.
Conclusion
The crystal structure reveals that the compound forms chains linked by hydrogen bonds and stabilized by π–π interactions.
Supporting Evidence
- The compound was obtained as part of ongoing research on pazopanib derivatives.
- The indazole and pyrimidine rings form a dihedral angle of 23.86°.
- Hydrogen bonds link the molecules into chains in the crystal structure.
- Intermolecular π–π interactions help stabilize the crystal packing.
Takeaway
Scientists studied a new chemical compound and found out how its molecules are arranged in a solid form, which helps understand its properties.
Methodology
The crystal structure was determined using X-ray diffraction techniques.
Digital Object Identifier (DOI)
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