Overexpression of LIM-only 4 in Late Stage Pancreatic Cancer
Author Information
Author(s): Yu Jun, Ohuchida Kenoki, Nakata Kohei, Mizumoto Kazuhiro, Cui Lin, Fujita Hayato, Yamaguchi Hiroshi, Egami Takuya, Kitada Hidehisa, Tanaka Masao
Primary Institution: Kyushu University, Fukuoka, Japan
Hypothesis
LMO4 may be related to pancreatic carcinogenesis as it is in breast carcinogenesis.
Conclusion
LMO4 is overexpressed in pancreatic carcinomas at late stages of carcinogenesis.
Supporting Evidence
- 9 of 14 pancreatic cancer cell lines expressed higher levels of LMO4 mRNA than did the human pancreatic ductal epithelial cell line.
- In bulk tissue samples, expression of LMO4 was higher in pancreatic carcinoma than in non-neoplastic pancreas.
- IDC cells expressed significantly higher levels of LMO4 than did normal ductal epithelia or PanIN-1B cells.
Takeaway
The study found that a protein called LMO4 is found in much higher amounts in late-stage pancreatic cancer compared to normal cells.
Methodology
Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to measure LMO4 mRNA levels in various pancreatic cell types and tissues.
Limitations
The study had a small sample size for some analyses, particularly for PanIN-2 and non-invasive IPMC lesions.
Statistical Information
P-Value
p < 0.0001
Confidence Interval
95% CI, 0.16 – 0.32
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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