Impact of Device Variability on Kidney Function During Machine Perfusion
Author Information
Author(s): Lantinga Veerle A., Arykbaeva Asel S., Spraakman Nora A., Blom Elwin W. P., Huijink Tobias M., de Vries Dorottya K., Ploeg Rutger J., Alwayn Ian P. J., Leuvenink Henri G. D., Moers Cyril, van Leeuwen L. Leonie
Primary Institution: University Medical Center Groningen
Hypothesis
Different perfusion protocols and devices will significantly affect kidney function and perfusion parameters during normothermic machine perfusion.
Conclusion
The study found that perfusion characteristics and kidney function are significantly influenced by the perfusion protocol and the device used during normothermic machine perfusion.
Supporting Evidence
- The PL group had significantly lower arterial pO2 compared to the KA groups.
- Oxygen consumption was significantly higher in the PL group compared to the KA groups.
- The modified KA group showed significantly lower vascular resistance and higher oxygen delivery in human kidneys.
Takeaway
This study shows that how you pump blood into a kidney can change how well it works, so it's important to use the right method.
Methodology
Porcine kidneys were perfused using different devices and protocols, and human kidneys were tested with the best protocol identified.
Potential Biases
The study may have biases due to the small sample size and the nature of the experimental design.
Limitations
The sample size is small, limiting generalizability, and the kidneys were not transplanted, so the impact on transplant outcomes is unknown.
Participant Demographics
Porcine kidneys from six-month-old Dutch Landrace pigs and discarded human kidneys.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website