High prevalence and diversity of optrA-positive enterococci in Shenzhen, China
Author Information
Author(s): Fu Yulin, Deng Zhaoju, Shen Yingbo, Wei Weizhou, Xiang Qiumei, Liu Zhiyang, Hanf Kunning, Huang Suli, Lv Zexun, Cao Tingting, Peng Changfeng, Zhang Rong, Zou Xuan, Shen Jianzhong, Schwarz Stefan, Wang Yang, Liu Dejun, Lv Ziquan, Ke Yuebin
Primary Institution: Shenzhen Centre for Disease Control and Prevention
Hypothesis
The study investigates the prevalence and antimicrobial resistance of optrA-positive enterococci in a Shenzhen community.
Conclusion
The study found that optrA-positive enterococci exhibit high antimicrobial resistance and pose a significant public health threat.
Supporting Evidence
- 102 optrA-positive enterococci were isolated from feces of 719 healthy volunteers.
- High antimicrobial resistance rates were observed in OPEs compared to optrA-negative enterococci.
- Phylogenetic analysis showed high similarity between community strains and those from patients and animals.
- Most ARGs were co-located on optrA-carrying plasmids, indicating a significant public health threat.
Takeaway
This study shows that many bacteria in people's poop can resist important medicines, which is bad for health.
Methodology
102 optrA-positive enterococci were isolated from feces of 719 healthy volunteers, and their antimicrobial susceptibility was tested using whole-genome sequencing.
Potential Biases
Potential bias in volunteer selection and self-reported data.
Limitations
The study may not represent all communities due to its specific geographic focus.
Participant Demographics
Healthy volunteers from a Shenzhen community.
Statistical Information
P-Value
0.042
Confidence Interval
95% CI: 14.90–21.20%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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