Linkage Region for gPRA in Schapendoes Dogs
Author Information
Author(s): Lippmann Tanja, Jonkisz Anna, Dobosz Tadeusz, Petrasch-Parwez Elisabeth, Epplen Jörg T., Dekomien Gabriele
Primary Institution: Ruhr-University
Hypothesis
What is the molecular basis of canine generalized progressive retinal atrophy (gPRA) in Schapendoes dogs?
Conclusion
A region for gPRA was identified in Schapendoes dogs, but the mutation causing the condition has not yet been found.
Supporting Evidence
- Genotyping data showed a peak two-point lod score of 4.78 for marker REN93E07 on CFA20.
- Haplotype analyses inferred the gPRA locus in a 5.6 megabase region.
- Mutation screening in candidate genes revealed no causative sequence deviations.
Takeaway
This study looked at a group of Schapendoes dogs to find out what causes a vision problem called gPRA, and they found a specific area in their DNA that might be important.
Methodology
Whole-genome scanning for linkage using microsatellite markers and haplotype analyses.
Limitations
The exact mutation causing gPRA has not been identified yet.
Participant Demographics
57 Schapendoes dogs, including 13 affected by gPRA.
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
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