Radiotherapy and Hyperbaric Oxygen for Malignant Gliomas
Author Information
Author(s): Kohshi K, Kinoshita Y, Imada H, Kunugita N, Abe H, Terashima H, Tokui N, Uemura S
Primary Institution: University of Occupational and Environmental Health
Hypothesis
The study aims to evaluate the efficacy of radiotherapy combined with hyperbaric oxygen in patients with malignant glioma.
Conclusion
Irradiation after hyperbaric oxygen appears to be an effective treatment for malignant gliomas, especially when administered immediately after decompression.
Supporting Evidence
- 73% of patients in the HBO group showed significant tumor regression.
- Median survival was 24 months for HBO patients compared to 12 months for non-HBO patients.
Takeaway
This study found that giving radiation treatment right after a special oxygen therapy helped more patients with brain tumors get better.
Methodology
Patients were treated with nitrosourea-based chemotherapy and either received radiotherapy after hyperbaric oxygen or without it, with tumor responses assessed via imaging.
Participant Demographics
Patients with post-operative residual tumors from 1987 to 1997.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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