High FOXP3+ T-cell Density in Sentinel Lymph Nodes and Metastasis in Gastric Cancer
Author Information
Author(s): Lee H E, Park D J, Kim W H, Kim H H, Lee H S
Primary Institution: Seoul National University Bundang Hospital
Hypothesis
Can the immunologic nature of sentinel lymph nodes in gastric cancer patients predict non-sentinel lymph node metastasis?
Conclusion
High FOXP3+ Treg density in sentinel lymph nodes is an independent predictor of non-sentinel lymph node metastasis in gastric cancer.
Supporting Evidence
- High FOXP3+ Treg density was significantly associated with non-SLN metastasis.
- Univariate and multivariate logistic regression models confirmed FOXP3+ Treg density as an independent predictor.
- Median age of participants was 57.5 years, with a majority being men.
Takeaway
This study found that having a lot of certain immune cells in the lymph nodes can help doctors predict if cancer will spread to other lymph nodes.
Methodology
Sentinel lymph node samples were collected from 64 gastric carcinoma patients and analyzed for immune cell densities using immunostaining.
Potential Biases
Potential biases may arise from the selection of patients and the methods used for immunostaining.
Limitations
The study may not be generalizable due to the specific patient population and the relatively small sample size.
Participant Demographics
35 men and 29 women, median age 57.5 years.
Statistical Information
P-Value
0.033
Confidence Interval
1.000–1.003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website