TNF-alpha Boosts Melphalan in Tumors
Author Information
Author(s): de Wilt J H W, ten Hagen T L M, de Boeck G, van Tiel S T, de Bruijn E A, Eggermont A M M
Primary Institution: Department of Surgical Oncology, University Hospital Rotterdam Dijkzigt/Daniel den Hoed Cancer Centre
Hypothesis
Does adding TNF-alpha to melphalan during isolated limb perfusion increase the concentration of melphalan in tumor tissue?
Conclusion
Adding TNF-alpha to melphalan significantly increases the concentration of melphalan in tumor tissue during isolated limb perfusion.
Supporting Evidence
- A significant sixfold increase in melphalan concentration was observed when TNF-α was added.
- This increase provides a straightforward explanation for the synergistic effects of TNF-α and melphalan.
Takeaway
When doctors use a special treatment to deliver medicine to tumors, adding a substance called TNF-alpha makes the medicine work better by getting more of it into the tumor.
Methodology
The study measured melphalan concentration in tumor tissue after isolated limb perfusion with and without TNF-alpha.
Participant Demographics
Rats were used in the study.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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