Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours
2000
Stathmin Overexpression in Breast Cancer
Sample size: 133
publication
Evidence: moderate
Author Information
Author(s): Curmi P A, Noguès C, Lachkar S, Carelle N, Gonthier M-P, Sobel A, Lidereau R, Bièche I
Primary Institution: INSERM U440, IFM
Hypothesis
Is stathmin overexpression significant in breast cancer?
Conclusion
Stathmin overexpression is found in a subgroup of breast tumors and is associated with poor prognostic factors.
Supporting Evidence
- Stathmin was overexpressed in 22% of the tumors studied.
- Overexpression of stathmin was correlated with the loss of steroid receptors.
- There was a significant correlation between stathmin overexpression and histopathological grade III.
Takeaway
Some breast cancer tumors have too much stathmin, which might make them grow faster and not respond well to treatments.
Methodology
The study evaluated stathmin expression using reverse transcription polymerase chain reaction and correlated it with disease parameters.
Participant Demographics
Women with primary breast cancer.
Statistical Information
P-Value
0.0006; 0.008; 0.002; 0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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