Genetic Factors Affecting Warfarin Dose in Indonesians
Author Information
Author(s): Suriapranata Ivet M, Tjong Wen Ye, Wang Tingliang, Utama Andi, Raharjo Sunu B, Yuniadi Yoga, Tai Susan SW
Primary Institution: Mochtar Riady Institute for Nanotechnology
Hypothesis
What genetic factors influence warfarin sensitivity in ethnic Indonesians?
Conclusion
Genetic variants in CYP2C9 and VKORC1, along with non-genetic factors, account for 15.4% of the variability in warfarin dose among Indonesian patients.
Supporting Evidence
- CYP2C9 rs17847036 and VKORC1 rs9923231 were significantly associated with warfarin sensitivity.
- Age and body height were significantly correlated with warfarin dose.
- The study population consisted of unrelated ethnic Indonesians treated for thromboembolic diseases.
Takeaway
Some people need different amounts of a medicine called warfarin because of their genes. This study found that certain gene changes can help doctors give the right dose to Indonesian patients.
Methodology
The study analyzed SNPs in several genes related to warfarin metabolism and used multiple linear regression to model dose requirements.
Potential Biases
Potential bias due to the exclusion of patients with incomplete medication history.
Limitations
The study was conducted at a single center and may not represent all ethnic Indonesians.
Participant Demographics
{"gender":{"male":47,"female":38},"age":{"male":"58 ± 12","female":"56 ± 10"},"body_weight":{"male":"65.25 ± 10.41","female":"57.64 ± 14.27"},"body_height":{"male":"165.74 ± 6.74","female":"156.10 ± 5.06"}}
Statistical Information
P-Value
0.0058
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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