The Role of PagN Protein in Salmonella Typhimurium
Author Information
Author(s): Lambert Matthew A, Smith Stephen GJ
Primary Institution: Trinity College Dublin
Hypothesis
PagN may function as an adhesin and invasin in Salmonella Typhimurium.
Conclusion
PagN is an outer membrane protein that contributes to the virulence of Salmonella Typhimurium by mediating adhesion to and invasion of mammalian cells.
Supporting Evidence
- PagN can agglutinate red blood cells when expressed in E. coli.
- S. Typhimurium pagN mutants show reduced adhesion to and invasion of epithelial cells.
- Over-expression of PagN can partially compensate for the lack of a functional invasasome.
Takeaway
PagN helps Salmonella stick to and invade cells in the body, which is important for the bacteria's ability to cause disease.
Methodology
The study involved expressing the PagN protein in E. coli and testing its ability to agglutinate red blood cells and invade mammalian cells.
Limitations
The study primarily used E. coli models and may not fully represent Salmonella behavior in natural infections.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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